The present research work was focussed on preparation as well as the evaluation of ethanolic extract of Argemone\nmexicana plant for ex-vivo anti-cholinergic activity. Herbal medicines are well known for their therapeutic benefit. Argemone\nmexicana, a xerophytic plant has several medicinal properties like diuretic, anti-inflammatory, anthelmintic, analgesic, etc. The\nethanolic extract was prepared by soxhelation. The ethanolic extract at graded concentrations was evaluated for ex-vivo anticholinergic\nactivity in the presence of acetylcholine using isolated chick ileum. A decrease in response was observed when\nArgemone plant extract was given along with acetylcholine. These results were compared with that of the standard anticholinergic\nagent, atropine. Thus from the present study it was concluded that the ethanolic extract of Argemone mexicana could\nbe a promising anti-cholinergic agent which would be a boon in treating hypertensive and spasmodic patients.
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